ADHD Medication Battle: Vyvanse vs Concerta

This article is a summary of the YouTube video ‘Which ADHD Medication Is Best? (Comparing Concerta Vs Vyvanse)’ by Dr. Aly Wood

Written by: Recapz Bot

Written by: Recapz Bot

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How does it work?
Concerta and Vyvanse are ADHD medications with different characteristics and side effects, but both are effective.

Key Insights

  • Concerta (methylphenidate extended release) and Vyvanse (lisdexamphetamine) are commonly prescribed ADHD medications.
  • Concerta is in the methylphenidate group, while Vyvanse is in the amphetamine group.
  • Concerta is FDA approved for the treatment of ADHD and narcolepsy, while Vyvanse is approved for ADHD and binge eating disorder.
  • Concerta comes in tablets, while Vyvanse comes in capsules and chewable form.
  • Both medications increase the activity of dopamine and norepinephrine in the brain.
  • Concerta has an asthmatic release oral system that releases the medication in a controlled manner over 10-12 hours, while Vyvanse remains inactive until enzymes in the body convert it into active dextroamphetamine, lasting around 12-14 hours.
  • Common side effects of Concerta include decreased appetite, headaches, dry mouth, nausea, and insomnia. Common side effects of Vyvanse include decreased appetite, insomnia, upper abdominal pain, irritability, and vomiting.
  • Both medications can cause temporary slowing in growth rate and weight loss, especially in children and teens.
  • The cost of Concerta is more affordable with generic options available, while Vyvanse is only available as a brand version.
  • Studies show that both medications are more effective than placebo in the treatment of ADHD, but Vyvanse may have a statistically significant greater improvement in symptoms compared to Concerta.
  • Concerta may be better tolerated than Vyvanse, especially in children and teens.
  • Additional studies and information can be found in the video.

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Transcript

Title: Concerta vs Vyvanse: A Comparison of ADHD Medications

Introduction:
Concerta and Vyvanse are two commonly prescribed ADHD medications. In this video, we will compare them to help you determine which one is best for you. Let’s start by clarifying the names of these medications: Concerta is the brand name for methylphenidate extended release, and Vyvanse is the brand name for lisdexamfetamine. Both belong to the stimulant category of medications and work by increasing dopamine and norepinephrine activity in the brain.

Conditions treated:
Concerta is FDA approved for the treatment of ADHD and narcolepsy in adults, while Vyvanse is approved for ADHD and binge eating disorder. Both are also approved for the treatment of ADHD in children aged 6 and older. Additionally, they are used off-label for obesity and treatment-resistant depression.

Dosage and administration:
Concerta comes in tablet form with a daily dose range of 18-72 milligrams. It is important not to crush or chew the tablets. Vyvanse comes in capsule form with a daily dose range of 10-70 milligrams. The capsule can be opened and mixed with orange juice, yogurt, or water. Vyvanse also has a chewable form available, which is strawberry flavored.

Mechanisms of action:
Concerta is in the methylphenidate group and utilizes an osmotic release oral system (OROS). The tablet has an outer immediate release layer with the remaining dose contained inside compartments. The tablet absorbs water in the digestive system, causing the pressure to increase and gradually release the medication through laser-drilled holes. Concerta typically lasts in the system for 10-12 hours. It is important to note that the medication shells are not digested and may appear in the stool.

Vyvanse is unique as it has a lysine chemical bound to it, making it inactive until it is orally ingested. Enzymes in the body then cleave off the lysine, converting it into active dextroamphetamine. This design helps reduce potential abuse or diversion of the medication. Vyvanse lasts around 12-14 hours on average.

Side effects:
The most common side effects of Concerta include decreased appetite, headaches, dry mouth, nausea, and insomnia. For Vyvanse, the common side effects are decreased appetite, insomnia, upper abdominal pain, irritability, and vomiting.

Effects on growth:
According to medication labels, consistent use of Concerta in children may temporarily slow down growth by approximately 2 cm in height and result in a weight loss of around 2.7 kg (6 lbs). Vyvanse studies show dose-dependent weight loss, with higher doses potentially leading to more significant weight loss. Monitoring growth and weight is crucial for children and teens on these medications.

Cost:
Concerta is available in both brand and generic versions, making it more affordable if insurance coverage is an issue. Vyvanse is currently only available in the brand version, but a generic option is expected in 2023.

Research and effectiveness:
Various studies have compared Vyvanse and Concerta. One study showed that Vyvanse had a greater improvement in ADHD symptoms compared to Concerta. Another analysis found a statistically significant better probability of response for Vyvanse compared to other methylphenidate formulations and non-stimulant options. However, treatment adherence and tolerability should also be considered. Studies suggest Concerta is better tolerated, particularly in children and teens, while amphetamine-based products like Vyvanse may be preferred for adults.

Conclusion:
Both Concerta and Vyvanse are effective in treating ADHD symptoms. However, based on current research, Vyvanse may offer slightly better results in symptom improvement. Treatment adherence and tolerability should be taken into account when choosing a medication. Concerta is generally better tolerated, especially in children and teens, whereas Vyvanse may be preferred for adults. Discussing these options with your healthcare provider is recommended.

[End of transcript]

This article is a summary of the YouTube video ‘Which ADHD Medication Is Best? (Comparing Concerta Vs Vyvanse)’ by Dr. Aly Wood